ALLEN Developing Mouse Brain Atlas TECHNICAL WHITE PAPER: REFERENCE ATLASES FOR THE ALLEN DEVELOPING MOUSE BRAIN ATLAS

The Allen Developing Mouse Brain Atlas provides a cellular-resolution map of gene expression in the developing mouse brain from the embryo to the young adult. To provide a neuroanatomical framework for expression data, reference atlases for the Allen Developing Mouse Brain Atlas were created with the expertise of Professor Luis Puelles, M.D., Ph.D. (University of Murcia, Spain). Sagittal full-color, high resolution web-based digital reference atlases have been created for seven stages of mouse brain development (Fig. 1). A novel anatomic classification system or “ontology” provides ontogenetic relationships between brain regions which is based upon concepts derived from developmental neurobiology, as explained further below.